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Ohio River Cruise

Ohio River Cruise

At a glance

Duration: 11 Days, 10 Nights

Coverage: St. Louis, MO to Pittsburg, PA

From: $5,510

Season: June - July

Activities: Culture, History, Photography

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American Cruise Lines

Experience the picturesque waterways of the Mississippi and Ohio Rivers on this 11-day adventure. Your journey begins at the Gateway Arch Riverfront in St. Louis and continues to the historic river port town of Cape Girardeau. In Paducah, view the more than 50 life-sized panoramic murals that decorate the shoreline and paint a vivid picture of the city’s past. Visit the John James Audubon Museum in Henderson, featuring many original oil and watercolor paintings created by this famous artist. While in Louisville, get a behind the scenes tour of the Churchill Downs, the site of the famed Kentucky Derby, and sample the finest bourbon at the famous Jim Beam Distillery. At the Underground Railroad Freedom Center in Cincinnati, learn about the sacrifices made so that the enslaved could escape to freedom. In Maysville, enjoy the idyllic countryside and native sounds of original bluegrass music.

Step back in time to the grand era of paddlewheels as we explore the heartland of America. While the churn of the paddlewheel blends with the sounds of the river, rediscover the America of the pioneers, boundless optimism, and unlimited possibilities.

Day-to-Day Itinerary

Pre-Cruise - St. Louis, MO

Each Mississippi itinerary comes complete with a Complimentary Pre-Cruise Package, providing you with a seamless way to board the ship and explore the local area. Arrive the day before your scheduled cruise date and American Cruise Lines will handle the rest. The package includes a premium hotel stay, where you can enjoy the city at your leisure. On the morning of the cruise, meet in the hotel lobby after breakfast and we will transport you to the ship to begin your cruise. All luggage will be brought directly from the hotel and placed in your stateroom aboard the ship.

*Pre-Cruise Package is not available for reservations made within 30 days of cruise date.

Day 1 - St. Louis, MO

St. Louis is sure to win you over. Admire the scenic riverfront, highlighted by the majestic Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis’ many world-class attractions, including the Art Museum, Science Center, and the Missouri History Museum. End your day at the Missouri Botanical Garden, one of the world’s most popular public gardens.

Day 2 - Cape Girardeau, MO

Enjoy the charming features of this historic town that in the late 1800s was a French trading post and lively river port. Today, it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich heritage and enjoy shore excursions to Cape River Heritage Museum and the Red House Interpretive Center.

Day 3 - Paducah, KY

Residing at the confluence of the Tennessee River and the Ohio River, Paducah will make you feel as if you stepped back in time. As you walk the streets of this Chickasaw village site, discover Paducah’s rich history. View the Wall-to-Wall Mural Program, a collection of over 50 murals that covers a number of subjects including Native American history, the Civil War, and area landmarks such as the Old Carnegie Library.

Day 4 - Henderson, KY

You won’t miss the presence of the notable resident, John James Audubon, whose “Birds of America” paintings are recreated as bronze statues throughout Henderson. Named after President Washington’s home on the Potomac, this bucolic river town is steeped in fascinating lore. Let our expert guide lead you on a tour of our famous first President's historic home and grounds.

Day 5 - Day of River Cruising

Sit back and enjoy the gentle sounds of the paddlewheel as it churns along the placid waters of the Ohio River. Delight in the picturesque and ever-changing scenery as it passes by, and experience the river as early explorers did centuries ago.

Day 6 - Louisville, KY

Named after King Louis XVI of France, Louisville is best known for the famed Kentucky Derby, the first leg of the Triple Crown of Thoroughbred Racing.Discover why Louisville is often referred to as either the northernmost southern city or the southernmost northern city in the United States.

Day 7 - Cincinnati, OH

Enjoy a visit to Cincinnati, a vibrant city and cultural center which boasts two major sports franchises, as well as numerous theatres and museums. Explore its picturesque streets, abounding in eclectic architecture.

Day 8 - Maysville, KY

Maysville, KY is a quaint town on the Ohio River with a rich history. An important stop on the Underground Railroad, Maysville was host to Harriet Beecher Stowe in 1883. Your stop will include idyllic country scenery and the native sounds of original bluegrass country music.

Day 9 - Day of River Cruising

Grab a good book and curl up in one of our spacious lounges as the Queen of the Mississippi makes its way down the Ohio River. Bird watchers and nature enthusiasts will find the top deck to be the ideal location to identify different species of birds and other wildlife that call the Ohio River home.

Day 10 - Marietta, OH

The second-largest city in the Parkersburg-Marietta-Vienna Metropolitan area, Marietta was named in honor of Marie Antoinette. During the 18th and 19th-century, the town experienced economic prosperity, as its location on the Ohio River made it an attractive stop for commercial steamboats and travelers.

Day 11 - Pittsburgh, PA

End your journey in the "steel city," Pittsburgh, PA. Long known for steel manufacturing, Pittsburgh was an essential stop along the Ohio River for national and international commerce, making it a wealthy town in the 18th and 19th centuries.

Ohio River Cruise Itinerary Map

Dates & Rates

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Date Direction Ship A AAR AAL AAC AAM Owner's Suite Single Single w/ Balcony
Jun 25, 2019 St. Louis, MO to Pittsburgh, PA Queen of the Mississippi $5,510 $6,220 $6,765 $7,095 $7,570 $9,125 $7,070 $7,815
Jul 5, 2019 Pittsburgh, PA to St. Louis, MO Queen of the Mississippi $4,635 $5,295 $5,805 $6,110 $6,555 $8,005 $5,590 $6,280
Jul 15, 2019 St. Louis, MO to Pittsburgh, PA Queen of the Mississippi $5,135 $5,795 $6,305 $6,610 $7,055 $8,505 $6,590 $7,280
Jul 25, 2019 Pittsburgh, PA to St. Louis, MO Queen of the Mississippi $5,135 $5,795 $6,305 $6,610 $7,055 $8,505 $6,590 $7,280
Jun 23, 2020 St. Louis, MO to Pittsburgh, PA Queen of the Mississippi $5,510 $6,220 $6,765 $7,095 $7,570 $9,125 $7,070 $7,815
Jul 3, 2020 Pittsburgh, PA to St. Louis, MO Queen of the Mississippi $5,135 $5,795 $6,305 $6,610 $7,055 $8,505 $6,590 $7,280
Jul 13, 2020 St. Louis, MO to Pittsburgh, PA Queen of the Mississippi $5,135 $5,795 $6,305 $6,610 $7,055 $8,505 $6,590 $7,280
Jul 23, 2020 Pittsburgh, PA to St. Louis, MO Queen of the Mississippi $5,135 $5,795 $6,305 $6,610 $7,055 $8,505 $6,590 $7,280

Prices displayed are per person based on double occupancy. A deposit of $500.00 per person is required to confirm any reservation on trips of 9 nights or less, and a deposit of $900.00 per person is required to confirm any reservation on trips of 10 nights or more. Final payment is due 90 days prior to the sailing date. Any Reservation made within 90 days of the departure date must be accompanied by full payment and is subject to Cancellation Terms.


Queen of the Mississippi

Queen of the MississippiQueen of the Mississippi delivers an experience unlike any other riverboat. Queen of the Mississippi offers passengers modern amenities and comforts including large staterooms with private balconies, hotel-style bathrooms, complimentary room service, WiFi, and more. Built in 2015, the Queen of the Mississippi offers an authentic paddlewheeler experience with all the comforts of home.View ship details...